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Charles River Laboratories Principal Scientist 3, Metabolite ID in Worcester, Massachusetts

Principal Scientist 3, Metabolite ID

Req ID #: 132693


Worcester, MA, US, 01608

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

We have an exciting opportunity for aPrincipal Scientist 3, Metabolite IDat ourDiscoverysite located inWorcester, MA.

Serve as senior scientific team member with overall responsibilities for the scientific and operational management of metabolite identification programs supporting a variety of early to late stage in vitro ADME and in vivo PK studies. Provide support and direction for one or more functional areas of expertise critical to the business objectives of the company. Responsible for mentoring and management of more junior staff across multiple programs, scientific areas and client interactions.

Essential responsibilities:

  • Function independently as the Study Director/Principal Investigator and technical expert in the metabolite profiling and identification area. Develop, perform, and troubleshoot bioanalytical laboratory experiments, tests, and procedures supporting in vitro ADME and in vivo PK studies within accepted regulatory compliance and in a timely manner which meet client needs.

  • Function as the primary contact for the planning and execution of Sponsor interaction related to research and method development, and for the design, scheduling, conduct and reporting of studies with a primary focus on metabolite identification projects.

  • Ensure raw data is accurate, complete, timely and in appropriate order to meet protocols and SOP specifications.

  • Possess exceptional organizational and planning skills enabling management of multiple, concurrent tasks and priorities.

  • Prepare high quality final reports appropriate for the study including method development, method optimization, sample analysis and data interpretation.

  • Provide oversight of the laboratory and mentor scientific staff in areas such as protocol interpretation, method development and refinement, study-related problem resolution, and technique validation. Provide scientific expertise in study conduct, design, and interpretation.

  • Perform advanced troubleshooting on analytical instrumentation including liquid chromatography and mass spectrometry systems.

  • Direct the development and communication of departmental systems, SOPs, policies, and procedures.

  • Attend and present novel work at scientific meetings.

  • Primary point of contact for sponsor relationships.

Job Qualifications

The following are minimum qualifications related to thePrincipal Scientist 3, Metabolite ID position:

Education: Bachelor's degree (B.S./B.A.) or equivalent in a scientific related discipline. Related Master's degree (M.S./M.A.) or Ph.D. preferred.

Experience: Minimum of 9 years related experience in the contract research, academic, or pharmaceutical industry.

An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.

Certification/Licensure: Certification as appropriate for specialty preferred.

Other: Full understanding of regulatory requirements of study types assigned, as well as Testing Facility SOPs, as appropriate. Knowledge of applicable international guidelines for all types of studies. Demonstrate leadership skills as they pertain to intra- and interdepartmental initiatives, Sponsor interactions, and business development. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of standard software including Microsoft® Excel, Word, PowerPoint, etc. and analytical instrumentation software.

About Discovery

Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 85% of the drugs approved by the FDA in 2019.

Equal Employment Opportunity

Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

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