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ManpowerGroup Senior Research Associate, Pilot Lab, Gene Therapy in Waltham, Massachusetts

Resilience is seeking a Senior Research Associate to build innovative viral vector programs, products, and processes. This individual will join a growing viral vector group in the Gene Therapy Franchise responsible for development and tech transfer of AAV, LVV, and other viral-based therapies. The successful candidate will develop and optimize pilot-scale work, support technology transfer of processes to the Resilience network of viral vector cGMP manufacturing facilities, and examine state of the art technology platforms and disruptive approaches to vector production at pilot scale. The Senior Research Associate will actively interact with internal manufacturing, analytical development, QC, QA and external collaborators to develop and drive program, product, and process-specific initiatives.

This individual should be instinctively drawn to problems and driven to simplify and solve them. They are resourceful and creative, using constraints as forcing functions for nonlinear gains. Details matter. Speed is a virtue. They never lose sight of the patients who are the ultimate beneficiaries of our efforts.

Job Responsibilities

  • Execute Viral Vector Pilot studies at scales up to 200L using single-use systems

  • Screen methods and processes to optimize AAV vector production, working alongside our Process Development team to ensure a smooth and seamless end-to-end process transfer to GMP manufacturing

  • Document process parameters, bill of materials, and equipment to facilitate technology transfer using a process flow diagram

  • Develop scalable process parameters, expressed as dimensionless units, where feasible

  • Serve as a subject matter expert (SME) for process transfer and investigations at cGMP facilities

  • Assist with organizing and streamlining work activities, including,

  • Ensuring adequate and appropriate inventory of materials and supplies

  • Ensuring equipment is appropriately maintained and calibrated

  • Interacting with suppliers on design, procurement and testing of PD equipment

  • Ensuring documentation and data management practices are followed, reviewing documentation

  • Support collaborations with partners, technology developers, and suppliers

Qualifications

  • Master's degree with 0-2 years or B.S. with 3-5 years of experience in a technology-driven industry setting.

  • Capable of applying scientific principles and concepts to potential innovative platforms and disruptive technologies

  • Strong cell culture skills with fundamental understanding of viral production biology

  • Experience with Bioreactors up to 200L

  • Experience with depth filtration and clarification methods

  • Experience with experimental design, data analysis and organization

  • Enthusiasm about developing digital lab and data workflows

  • A self-starter and team player who can balance the needs of an entrepreneurial environment with the requirements of a GMP environment

Preferred Experience

  • Exposure to AAV production processes.

  • Experience with downstream processes, e.g. TFF and Chromatography

  • Experience with analytical or statistical software, e.g. JMP, Softmax Pro, XLfit, Gen5, etc.

  • GxP experience

Other Ideal Personal Characteristics

  • Hungry, humble, and a learning machine with an open, inquisitive mind regarding the future of medicine and biomanufacturing

  • Embodies the Resilience phenotypes of grit, rigor, service, EQ+IQ, builder mentality, velocity, and ownership

  • Smart, curious, flexible, able to contribute at a very high level, as well as possessing a hands-on manner, when necessary

  • Collaborative style, with an ability to build consensus among both internal and external stakeholders

  • A person of unquestioned integrity and moral character; an individual that others can trust without reservation

ManpowerGroup is committed to providing equal employment opportunities in a professional, high quality work environment. It is the policy of ManpowerGroup and all of its subsidiaries to recruit, train, promote, transfer, pay and take all employment actions without regard to an employee's race, color, national origin, ancestry, sex, sexual orientation, gender identity, genetic information, religion, age, disability, protected veteran status, or any other basis protected by applicable law.

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