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ElevateBio Scientist / Sr. Scientist, Stem Cell Biology - Regenerative Medicine Team in Waltham, Massachusetts

Title: Scientist / Sr. Scientist, Stem Cell Biology

Location: Waltham, MA

Reports to: Director, Regenerative Medicine

The Role:

ElevateBio is actively recruiting a Scientist / Sr. Scientist, Stem Cell Biology. This individual will report to the Director, Regenerative Medicine and will possess excellent scientific/technical skills. This person will be a part of the R&D team to establish hypoimmunogenic iPSC lines for the development of iPSC-derived cell therapies.

Here?s What You?ll Do:

  • Lead and execute activities supporting development and characterization of hypoimmunogenic iPSCs

  • Design and execute in vitro immunogenicity studies to characterize the interaction between immune system and iPSCs/derivatives

  • Manage CROs for outsourced in vivo research activities, including study design, monitoring, and data analysis

  • Generate, culture and bank iPSCs. Differentiate iPSCs into different cell types

  • Participate in the development of genetically modified iPSC lines

  • Interact closely with project teams and represent Regenerative Medicine group in cross-functional team forums

  • Contribute to scientific literature and at scientific conferences, as appropriate

  • Supervise junior scientists, as appropriate

Requirements:

  • PhD with 5-8 years of relevant experience; or a MS with 8-10 years of industrial experience, or BS with 10+ years of industrial experience

  • Three or more years of industry experience preferred

  • Expertise in transplant immunology and immune-evasion strategies for allogeneic cell therapies

  • Hand-on experience with in-vitro immunology workflows including cytotoxicity assays, cytokine profiling, proliferation assays, flow cytometry, ELISA and ELISpot

  • Strong knowledge of in vivo immunogenicity assessment employing syngeneic and allogeneic hosts.

  • Demonstrated experience in stem cell biology including reprogramming, iPSC characterization and differentiation

  • Experience in managing CRO is preferred

  • Experience in gene editing is a plus

  • Detail-oriented, organized, and technically competent

  • Highly adaptable and responsive, and committed to completing tasks in a timely fashion

  • Demonstrated ability to work in a dynamic environment as a team player with a strong work ethic

  • Excellent team player with good interpersonal and communication skills

  • Excellent oral and written communication skills, including supporting documentation in laboratory notebooks and study reports for regulatory filing activities

Why join ElevateBio?

ElevateBio is accelerating the future of biotechnology; developing the next-generation of cell, viral and regenerative medicine therapeutics for the treatment of severe diseases. We have launched a revolutionary new model that integrates innovators, infrastructure and capital to effectively develop cell, gene and related therapies for patients with severe and life-threatening disorders. With plans for a cutting-edge laboratory and manufacturing center already underway, we're building a world-class organization lead by expert talent with bench-to-bedside capabilities. ElevateBio is also a leader in corporate philanthropy and has taken a pledge to donate a portion of product sales to fund promising cancer research and to support cancer care in the developing world.

At the heart of the ElevateBio platform is ElevateBio Base Camp, a state-of-the-art research, development and manufacturing center for innovation in the Greater Boston Area to be staffed with a world-class team of scientists.

Our Vision:Next-generation product development for advanced therapies supported by global bench-to-bedside expertise shared across our portfolio of companies

ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person?s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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