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Sanofi Group mRNA - Scientist – Delivery & Formulation Development - Vaccine in Waltham, Massachusetts

In the race for the future of health – The Sanofi mRNA Center of Excellence ( CoE )

At Sanofi, we chase the miracles of science, and we know mRNA has a role to play in the future of health. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines and treatments for more people faster than before.

That’s why we’re looking for bold, optimistic world-changers to join our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of 450 dedicated employees, and focusing on implementing an integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.

Bring your ambition and optimism and join us on our journey to discover and deliver transformative medicine to patients through the advancement of our cutting-edge mRNA technology!

About the Opportunity

As an experienced mRNA Scientist, you will develop novel lipid nanoparticle (LNP) formulations for mRNA delivery.

Key Responsibilities for the Position:

In this role you will:

  • Lead formulation development of mRNA drug targets entailing: LNP formulations for in vitro/in vivo studies

  • Evaluate novel ideas for formulation optimization and increasing stability of formulations

  • Develop novel formulations and explore new processes for formulation design

  • Work closely and build relationships with select CROs with focus on in vivo studies, drug carrier design/development, assay development

  • Prepare technical reports and presentations for clear communication of scientific findings across interdisciplinary teams

  • Promote innovation, state of the art technologies and propose strategies using publications to improve the products.

  • Make scientific presentations and report project progress within mRNA CoE Formulation teams and with partners and in international forums.

Competencies / Requirements for Position

  • PhD in Chemistry/Physical Chemistry/Chemical Engineering/Pharmaceutical Sciences

  • 0 - 6 years of relevant experience in nucleic acid delivery with hands-on experience in lipid nanoparticle (LNP) formulations & characterization

  • Demonstrated success in nucleic acid delivery and the development of novel drug carriers with hands-on

  • Experience in lipid nanoparticle (LNP) formulations, polymer-based nanoparticles & characterization

  • Direct experience with messenger RNA encapsulation/quantification/characterization/handling is preferred

  • Proficiency in analytical techniques like HPLC/UPLC, DLS, CD, zeta potential, UV-Vis and fluorescence spectrophotometry etc. is preferred

  • Understanding and success in implementation of RNA-related analytics (Ribogreen, gel electrophoresis, capillary electrophoresis, etc.) is desired

  • Experience in developing LNP formulations for Gene/ cell immunotherapy would be advantageous

  • Works collaboratively within group as well as within interdisciplinary teams

  • Manages time effectively demonstrating ability to perform multiple projects at one time

  • Desire to work in a fast-paced environment

  • Excellent organizational and communication skills

  • Strong analytical and problem-solving skills

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. This position will require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

#GD-SP

#LI-SP

#mRNA

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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