Sanofi Group mRNA - Engineer Process Development - Drug Substance - Vaccine in Waltham, Massachusetts
In the race for the future of health – The Sanofi mRNA Center of Excellence ( CoE )
At Sanofi, we chase the miracles of science, and we know mRNA has a role to play in the future of health. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines and treatments for more people faster than before.
That’s why we’re looking for bold, optimistic world-changers to join our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of 450 dedicated employees, and focusing on implementing an integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.
Bring your ambition and optimism and join us on our journey to discover and deliver transformative medicine to patients through the advancement of our cutting-edge mRNA technology!
About the Opportunity
As an Engineer in the Global Drug Substance Development group, you will focus on development, optimization and scale-up of mRNA synthesis and purification processes with the goal of transferring at scale methods to either the internal or external manufacturing team for GMP manufacturing of mRNA drug substance. Experience with QbD approaches to ensure process robustness is essential.
In this role you will….
Develop scalable bench scale processes for mRNA drug substance material generation.
Responsible for applying scientific expertise and judgement to initiate, design, direct, and execute development studies to optimize and scale-up the mRNA process
Analyze, interpret, and summarize results in reports and presentations that support process development activities and process improvements
Work independently, pro-actively, and be an impactful contributor to project teams
Able to transform novel approaches into routine practice.
Effectively communicate with cross functional teams like Analytical Development, R&D, Tech Transfer, QA, and Project Management teams.
Support and contribute to IND filings/regulatory documentation.
Assist in the training of new research associates and other junior teammates
Biochemistry, engineering or related degree; PhD with 1 to 4 years, MS with 3 to 6 years or BS with 5 to 8 years of relevant industrial experience. Experience in large molecule drug substance development.
Experience with enzyme reactions, mixing, depth filtration, tangential flow filtration, and chromatography
Previous work with mRNA (handling/isolation/quantification/characterization) is desired
Knowledge of mRNA methods preferred
Capable of working in a collaborative team environment both within group and on interdisciplinary teams
Desire to work in a fast-paced environment
Excellent organizational and communication skills
Strong analytical and problem-solving skills
Ability to work in a fast-paced environment
Good oral communication, management, and interpersonal skills.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.
According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.
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