Massachusetts Green Jobs

Genomic Medicine Purification Process Development Co-Op, Waltham, MA

Position Overview/Department Description

• The Genomic Medicine Unit (GMU) Chemistry, Manufacturing and Control (CMC) group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant Adeno-associated viral vectors (AAV), non-viral and cell therapy products. This 6-month position centers on drug substance process development for gene therapy but will interface with a broader team of vector and cell line engineering, upstream process development, analytics, and clinical manufacturing support.

• A successful candidate in this role will be engaged in actively learning new techniques, independently performing experiments, analyzing and presenting results, and collaborating with different functions to understand the cross-functional nature of decision-making.

• Experience in protein characterization, high-throughput, engineering and data analysis, analytical techniques, and/or viral vector purification is preferred. Project topic will be commensurate with level of previous experience.

Key Responsibilities

• Design, and execute viral vector purification experiments.

• Perform analytical characterization of samples and analyze results.

• Work with cross-functional team for feedback and present findings.

• Contribute to technical reports and/or external publications if appropriate to project topic and level of experience.

Basic Qualifications

• Currently pursuing PhD, MS, or BS study in chemistry, chemical engineering, or biological engineering with relevant study experience.

• Understanding of drug substance purification process concepts.

• Theoretical and practical knowledge of mass transfer and fluid dynamics.

• Knowledge and understanding of technologies and operations such as:

• Chromatography, tangential flow filtration, normal flow filtration, and/or viral clearance and inactivation

• Advanced analytical tools to characterize particles and viral vectors

• Work under minimal supervision and function within a collaborative, team-oriented environment.

• Ability to work in Biosafety Level 2, follow safe lab procedures, and maintain good laboratory practices (GLPs) including detail-oriented laboratory notebook documentation.

Preferred Qualifications

• Experience with viral vector purification and characterization.

• Experience with SEC-HPLC, DLS, ddPCR/qPCR, Western blot, ELISA, spectroscopic and bioassay techniques.

• Experience with AKTA chromatography and filtration instruments.

• Experience with protein characterization such as NanoSight 3000, Caliper LabChip GXII, Multi-Angle LS (MALS), or similar instruments.

• Basic understanding of the principles of Quality by Design and ability to apply DOE to downstream development.

• Excellent communication skills and ability to build cross-functional relationships.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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