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Novo Nordisk Senior Scientist - Non Viral Delivery in Lexington, Massachusetts

About the Department

Dicerna, a Novo Nordisk company, is focused on driving innovation in RNAi (ribonucleic acid interference) to selectively target and silence genes that cause or contribute to disease. Our proprietary GalXC™ and GalXC-Plus™ RNAi technologies have the potential to address conditions that are difficult or impossible to treat with other modalities. Established as a Transformational Research Unit (TRU) following Novo Nordisk’s acquisition of Dicerna Pharmaceuticals, Inc. in December 2021, the Dicerna TRU is a unique new organization within Novo Nordisk that brings together the best of both worlds – the agility, collaborative pioneering spirit and calculated risk-taking profile of a biotech along with the scale, resources and capabilities of a global leader in drug development. With approximately 200 researchers, scientists, drug developers and operational staff, we are a team of inventive and entrepreneurial thinkers pushing the boundaries of science to create and drive new RNAi-based therapies for both rare and more prevalent diseases from the bench to the clinic. Together, we are driving change. Are you ready to make a difference?

The Position

The Senior Scientist in the Non-Viral Delivery department is a part of the RNA & Gene Therapy CVP team. In RNA & Gene Therapies, there are four specialized departments: non-viral delivery, Viral delivery, RNA Technologies, and Genome Editing. The Senior Scientist is a subject matter expert in design and synthesis of novel non-viral delivery systems, contributing to the overall success of RNA & Gene Therapy area in advancing the portfolio and applications of nucleic acid therapies.


Reports to Senior Director and head of Non-Viral Delivery.

Interacts with peers who specialize in non-viral delivery manufacturing and characterization, In vitro and in vivo bioassays and POC studies, Maturing platform, Peers in Malov, NVD, RNA> area wide, External partners and collaborators, GRT & GDD.

Essential Functions

  • As a Specialist in the Non-Viral Delivery department, you will become a part of a multinational and diverse team consisting of Laboratory Technicians, Specialist/Scientists, and a global department manager. The goal of the team is to develop synthetic/non-viral nanomedicines, apply advanced analytical characterization techniques and translate these to preclinical and clinical studies through internal and external collaborations

  • Identifies gaps in technological capabilities and therapeutic areas and provides recommendations to guide the research agenda

  • Represents the organization through external communication of impactful scientific research in the form of presentation at external conferences and publication in scientific journals and patents. May manage external collaborations

  • Provides significant mentorship and training of junior staff

  • Designing and applying lipids or other synthetic biomaterials for the syntheses of intracellular delivery systems

  • Routinely formulate and characterize LNPs at small to mid-scale using microfluidics

  • Evaluate LNP formulations using cell-based assays and collaborate with in vivo animal teams for platform screening

  • Optimize LNP formulations by medium to high-throughput screening to enhance therapeutic margins:

  • Develop and transfer development operations for producing high-quality LNP materials for large animal efficacy and toxicity studies to internal/external teams

  • Optimize long-term storage and stability conditions of LNPs

  • Develop robust analytical methods and bioassays for LNP CQA and CPP

  • Communicate findings internally to team via presentations and written reports

    Physical Requirements

    Some travel, national.


  • 18+ years’ relevant experience required or a master’s degree within subject matter expertise with 12+ years’ relevant experience or a Doctoral degree within subject matter expertise with 6+ years’ post-doctoral and/or industry relevant experience can be considered

  • Subject matter expertise in Organic Chemistry, Polymer Chemistry, Pharmaceutical Sciences, Drug Delivery, or related scientific disciplines

  • In-depth and hands-on experience in a range of synthesis, characterization, and purification techniques, including but not limited to NMR, HPLC (analytical and preparative), Mass Spectrometry, IR, silica gel and reverse phase chromatography, TLC, recrystallization etc.

  • Leading implementation of the LNP-based platform

  • Designing and applying lipids for the syntheses of lipid nanoparticles (LNP)

  • Acting as formulation subject matter expert for non-viral delivery of nucleic acid therapeutics. Experience with multiple formulation methods (microfluidics, T-mixer, etc.)

  • Experience with analytical method development for LNP size, concentration, encapsulation efficiency, potency assays, HPLC assays for lipid composition analysis, etc.

  • Experience with a broad range of molecular, cell-based assays and in vivo imaging/pooled formulations for evaluating delivery formulation performance is a must have

  • Experience tech transfer to GMP manufacturing, regulatory filings is desirable

  • Experience with high-throughput screening methods such as DoE for optimizing LNP formulations is a plus

  • Excellent verbal communication and interpersonal skills

  • Advanced understanding of lipid self-assembly mechanisms underpinning LNP formulations, mechanistic insights of LNP uptake and cytosolic availability of payload is desirable

  • Experience with SAXS/SANS/AF4, proteomics will be an attractive advantage

  • Demonstrate awareness of external trends, influences, and advances in the landscape of LNP delivery and clinical translation

  • Experience with automation is considered an advantage

  • Proven track record in publishing in HQ/HI journals on relevant topics. Seen as an expert in external consortia

    We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.

    At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.

    Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.

    If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-855-411-5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.