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Sage Therapeutics Scientist II, Translational Science in EMAIL:, Massachusetts

General Scope and Summary

SAGE Therapeutics is searching for a creative, resourceful, integrative thinker to play an important role in our Translational Science group. The Translational Scientist is responsible for identifying and validating translatable biomarkers of CNS function (‘target engagement’ or ‘proof of mechanism’ biomarkers) in support of our preclinical and clinical development stage programs. The ideal candidate will be an experienced in vivo physiologist with expertise in electrophysiology, CNS imaging, or other functional measures to interrogate brain circuitry, have a strong background in data analysis, and have an interest in guiding the biomarker strategy for Sage’s growing portfolio of programs.

Roles and Responsibilities

  • Design, oversee, and interpret in vivo physiology and imaging studies to evaluate the activities of small molecule drug candidates, investigate their mechanism of action, and explore novel hypotheses.

  • Manage and work with external CROs and academic collaborators responsible for conducting translational biomarker experiments.

  • Analyze datasets and work with other team members to integrate datasets and support PK/PD modeling activities.

  • Interact with project teams as a Pharmacology or Translational Science representative to facilitate information flow between the Translational Science function and the team.

  • Perform diligence to explore novel biomarker approaches and identify vendors and collaborators capable of performing experiments.

  • Prepare, review, and deliver scientific presentations and reports or manuscripts for internal and external use.

  • Collaborate effectively with colleagues across departments.

Experience, Education and Specialized Knowledge and Skills

Basic Qualifications

  • PhD in Neuroscience, Pharmacology, Biomedical Science, or related scientific discipline with 2+ years of relevant experience in the biotech/pharmaceutical industry; MS with at least 6+ years of relevant experience or BS with 8+ years of relevant experience.

  • Expertise in in vivo physiology or CNS imaging with a demonstrated track record of independent research.

  • A strong and established scientific background in neuroscience, pharmacology, or related field.

Preferred Qualifications

  • Ability to effectively work with others in a highly collaborative, matrixed research environment.

  • Excellent scientific and team-directed communication skills required.

  • Ability to prioritize responsibilities and be comfortable with changing direction and taking risks.

  • A thorough understanding of PK-PD relationships and drug discovery processes is an asset.

  • Knowledge of programming languages such as R, Python, and MATLAB would be helpful, but not required.

  • Ability to conduct independent research and be a team player.

  • Embrace our Core Values: Put People First, Do Big, Be Accountable, Grow through Learning and Change, and Work Fun.

  • Excitement about the vision and mission of Sage.

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All Sage new hires will be required to provide documentation that they are fully vaccinated against COVID-19 or, if not, that they are legally entitled to an accommodation due to a medical condition or a sincerely held religious belief. Requests for accommodation will be considered on a case-by-case basis, and Sage will consider, among other things, whether the proposed accommodation would create an undue hardship.

All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

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