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Cell Signaling Technology Research Associate II - Peptide Synthesis in Danvers, Massachusetts

Cell Signaling Technology, Inc. (CST) is a worldwide leader in the development and commercialization of antibodies, assays and research tools. As a company of scientists for scientists, we have developed PTMScan®, a technology to discover protein post-translational modifications, PhosphoSitePlus®, an online resource for investigation of post-translational modifications, and XMT® technology, a proprietary method to develop exceptional monoclonal antibodies. We are fully committed to developing new research tools to help define the mechanisms underlying cell function and disease, thereby broadly accelerating progress in biomedical research and medicine.

The mission of the Peptide Lab is to expeditiously synthesize and conjugate peptides to support all phases of the Product Development process, as well as the timely synthesis of peptides for any group within CST as requested. In addition, team members are expected to demonstrate a drive for innovation by analyzing the Lab’s work processes then devising and implementing ways to make the processes more technologically advanced, efficient and cost effective.

A successful Research Associate II will contribute to a highly efficient, cohesive team that satisfies the peptidyl needs of the Product Development process and other groups throughout the company, is comfortable working independently in a high throughput production environment with a repeating weekly work schedule, and demonstrates a drive for innovation in order to change or improve work processes.

  • Prepare peptide synthesis queues, programs and sets up peptide synthesizers.

  • Cleave and precipitate peptides after synthesis.

  • Prepare Purification Aliquot Plates and Blocking Aliquot Plates.

  • Pool peptide mixes and freeze drys the peptides on the lyophilizer.

  • Prepare QC samples for HPLC and Maldi-TOF analysis. Operates the HPLC and Maldi-TOF, acquires high quality data from the instruments.

  • Promptly update Peptide Notebook with relevant peptide synthesis information and QC data.

  • Troubleshoot peptides when first round of QC analysis fails to provide adequate data.

  • Conjugate all peptides in the weekly queue: peptides from the PLM Portal, Boosts, BSA conjugations for the Monoclonal Group.

  • Import Antibody Core conjugate information into the PLM Portal.

  • Perform HPLC purification of peptides.

  • Perform Amino Acid Analysis of purified peptides.

  • Coordinate with a variety of groups to quote, manufacture, package and ship for sale custom ordered peptides.

  • Inventory all raw materials and promptly places orders as necessary. Communicates supply issues to lab members.

  • Maintain and troubleshoot all lab equipment and instrumentation.

  • Arrange for service calls if problem is beyond the capability of the lab.

  • Respond to peptidyl inquires directed to the Peptide Lab in a timely, informative and professional manner.

  • Bachelor’s degree in Chemistry or Biology

  • 2-4 years' experience in a lab setting

  • Experience handling hazardous reagents and solvents

Preferred Skills/Experience

  • Excellent organizational skills, detail oriented

  • MS degree in Chemistry

  • 4+ years in a lab setting

  • Peptide synthesis experience

  • Experience using HPLC chromatography and/or MALDI-TOF mass spectrometry

  • Experience with automated instrumentation

  • Amino Acid Analysis experience

Cell Signaling Technology, Inc. is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, status as a veteran or as a member of the military or status in any group protected by applicable federal or state laws.

ID: 2021-1410

External Company URL:

Street: 3 Trask Lane