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Generation Bio Sr Scientist / Assoc Director, Molecular Pathology & Imaging Core Facility in Cambridge, Massachusetts

Generation Bio is an innovative genetic medicines company focused on creating a new class of non-viral gene therapy to provide durable, redosable treatments for people living with rare and prevalent diseases. The company’s non-viral platform incorporates a proprietary, high-capacity DNA construct called closed-ended DNA, or ceDNA; a cell-targeted lipid nanoparticle delivery system, or ctLNP; and an established, scalable capsid-free manufacturing process. The platform is designed to enable multi-year durability from a single dose of ceDNA and to allow titration and redosing if needed, and our scalable manufacturing process supports our mission to extend the reach of gene therapy to more people, living with more diseases, in more places around the world. Our vision is to make the ravages of genetic disease as imaginary to the next generation as polio feels to children today.

We are a thriving, collaborative, creative community of 120 people with diverse talents, beliefs, and experiences headquartered in Cambridge, Massachusetts.

Delve further. Please visit or follow @generationbio ( .


The Drug Safety and Translational Sciences department is seeking a scientist with histologic and molecular pathology expertise to help establish, develop and maintain a centralized molecular pathology and imaging facility that will support Generation Bio’s mission of delivering needed medicines to patients. The candidate will engage and support teams across the drug development process, expanding the understanding of non-viral gene therapies and diseases using tissue and cellular imaging.


Primary responsibilities include:

  • Laboratory design - conception through maintenance to support a growing organization

  • Design, develop and execution of molecular pathology assays. This includes workflows of single and multiplex IHC, ISH and FISH across multiple molecular platforms (including but not limited to autostainers and multispecteral imaging)

  • Oversee outsourcing and management of routine histology workstreams (including but not limited to tissue processing, embedding, and section of FFPE and OCT matrices, HE/ICH/ISH staining)

  • Develop new applications for cutting edge molecular pathology and image analysis techniques in the service of advancing the field of nonviral gene therapy and disease- specific pathology.

  • Timely communication and interpretation of data to Discovery & Development Teams

  • Organize and maintain image archives as appropriate


  • Minimum BS in molecular pathology or related field with 8 years of relevant experience; managerial experience a plus

  • Histologic expertise required, HT/HTL certificate preferred

  • Experience with diverse automated histology and molecular pathology platforms, image analysis software experience is preferred

  • Demonstrated ability to work in a highly matrixed organization and managing CRO vendors.

  • Demonstrated commitment to scientific inquiry, creative problem solving and lifelong learning

  • The ideal candidate will have had experience establishing a molecular pathology and imaging facility in a biotech setting with a strong collaborative and proactive presence across the organization

POSITION: Full-Time, Exempt

EEOC Statement: Generation Bio believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, gender, religion, national origin, gender identity, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Generation Bio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.