Pfizer Senior Scientist, Pharmacokinetics, Dynamics and Metabolism in Cambridge, Massachusetts


The successful candidate would be responsible for representing the Pharmacokinetics, Dynamics and Metabolism discipline (PDM or DMPK) in Drug Discovery projects primarily within the Inflammation and Immunology Research Unit and providing strategic direction to project teams from idea to NDA.


Responsible for representing PDM discipline in Drug Discovery projects primarily within the Inflammation and Immunology Research Unit and providing strategic direction to project teams from idea to NDA. This PDM role is central to many critical project team activities and involves amongst others, working with Bioanalytical and ADME scientists to design appropriate experiments in support of Project team needs, interfacing with biomarker scientists, PK/PD modelers and Research Unit partners to develop a translational pharmacology plan while key deliverables include Human PK predictions and dose projections for small molecule therapeutics. As PDM representative to the discovery project team, he/she will synthesize the PDM knowledge and influence the preclinical project plans and optimization of the therapeutic in a resource responsible manner. The project representative will interface with the asset development team to support the design and interpretation of ADME, drug interaction and special population PK studies, to prepare the regulatory dossier and respond to reviewer queries. The candidate will also partner with other PDM scientists to advance the ADME science and strategies for prosecuting small molecule projects.


  • PhD level education with 0-3 years (or MS/BS with 8 or more years) in a relevant field.

  • A strong record of scientific achievement and excellent communication skills as demonstrated through publications and presentations.

  • General knowledge of biotransformation and physical organic chemistry.

  • Understanding of bioanalytical sciences generally by LC-MS/MS.

  • Basic knowledge of Pharmacokinetics and drug disposition.

  • Basic understanding of ADME and in vitro drug metabolizing enzymes and transporters.


  • Integrating PDM discipline knowledge to help guide ADME strategy decisions.

  • General understanding of PK/PD modeling and its application to advance projects.

  • Mechanistic modeling/simulation of pharmacokinetics (e.g. SimCYP) experience preferred.

  • General understanding of drug discovery, chemistry and pharmacology.

  • Collaborative skills and effective partnering skills in a complex, multi-discipline organizational model.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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  • Last day to apply: October 26, 2018

  • Relocation eligible - Yes

  • Eligible for employee referral bonus - Yes

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.