Shire Senior Scientist - Analytical Research in Cambridge, Massachusetts

The primary role of this position is to generate key data for Proof of Concept (POC) and early develop-ability assessment for Research to Development transitions. This position will be designing and conducting biophysical and biochemical experiments for molecular function and develop-ability attributes. This candidate would be also responsible for characterizing biological molecules by structural, thermodynamic, kinetic and enzymatic functional characterization as part of molecular selection for development. An extensive knowledge and experience in structural biology and in-silico modeling of protein/antibody engineering are essential. Experience in Protein biochemistry and characterization techniques including MassSpec and light scattering based techniques are highly preferred.

The responsibilities for this role include planning, designing and execution of experiments using biophysical and biochemical methodologies; interpreting and presenting scientific data that contribute to our understanding of candidate selection and development transition. This candidate will manage CROs to provide analytical support needed for project teams. Also expected to explore new technologies to characterize recombinant/engineered macromolecules in alignment with department goals.


% of Time

Job Duty and Description


Planning and performing scientific experiments


Train fellow scientists with analytical techniques, manage CROs and explore new technologies for analytical characterization


Communicate with supervisor and fellow scientists regarding experimental design and results.


Prepare research reports and summary.

Education & Experience Requirements

A Ph.D. in Life Sciences with emphasis on structural biology, MassSpec, Biophysics, Physical Chemistry or Biochemistry is required. Five to ten years of combined academic/industry experience in macromolecules, especially in proteins and antibodies research, is required.

Other Job Requirements

Compliance to general lab safety, biohazard, radiation hazard and chemical hazard regulation is required.

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Equal Employment Opportunity

Shire is an Equal Opportunity Employer committed to a diverse workforce. Shire will not discriminate against any worker or job applicant on the basis of race, color, religion, gender, national origin, ancestry, age, sexual orientation, marital or civil partnership status, pregnancy, gender reassignment, non-job related mental or physical disability, genetic information, veteran status, military service, application for military service, or membership in any other category protected under law.

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Reasonable Accommodations

Shire is committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please call 484-595-8400 and let us know the nature of your request and your contact information.

Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal/Internal Medicine/Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.