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Editas Medicine Senior Research Associate/Associate Scientist I: LNP Delivery Technology - 2256 in Cambridge, Massachusetts

What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. We’re focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases. We’re looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before. Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you.

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise genetic modifications to treat a broad range of diseases. The Editing Technologies team optimizes current and new editing technology formats to provide gene editing solutions for current and future therapeutic programs. The team is looking to add highly talented and motivated indiviual to develop lipid nanoparticles (LNP) for advancing new therapies. The candidate will develop lipid nanoparticle (LNP) formulations, establish new LNP processes, develop characterization assays for LNP batches, and produce LNP-encapsulated gene editing agents for in vivo pre- clinical studies. The ideal candidate will be proactive, enthusiastic, and show a passion for developing delivery approaches that will be able to be adopted by process development. The applicant should have good communication and collaboration skills, along with a background in LNP formulation and characterization. The candidate will work within a cross-functional product development team including Formulation Development, mRNA Process Development, Analytical Development, Engineering, and Quality.

Key Responsibilities:

  • Develop and optimize the LNP formulation process to support pre-clinical in vivo delivery animal studies

  • Formulate mRNAs, guide RNAs, and other nucleic acid modalities to support company’s in vitro work and pre-clinical animal studies

  • Characterization of LNPs to support transition to process development groups

  • Play an important role in equipment design for scale up of LNPs for both pre-clinical and clinical development

  • Coordinate with the chemistry group at our Boulder, CO site and in vivo and in vitro Biology teams at our Cambridge, MA site.

  • Maintain a detailed electronic lab notebook and documentation records

Requirements

  • B.S./M.S. in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or other relevant scientific discipline.

  • 1-3 years of experience with some experience in (lipid) nanoparticle formulation and in vivo delivery of nucleic acid-based payloads

  • Experience with production and analytical characterization of mRNA and LNPs (e.g. zetasizer, absorption and fluorescence spectrometry, chromatographic separations, electron microscopy, etc.).

  • Familiarity with LNP screening, scale-up development, and/or regulatory aspects of mRNA-LNP products would be a plus

  • A record of success, demonstrated by work histoy, academic achievement, scientific publications, and carreer growth.

  • A team player with excellent oral and written communication skills and a demonstrated ability to work independently.

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