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Foghorn Therapeutics Scientist/ Sr. Scientist/ Principal Scientist, Computational Chemistry in Cambridge, Massachusetts

About Foghorn

Foghorn Therapeutics is pioneering the discovery and development of a new class of medicines targeting genetically determined dependencies within the chromatin regulatory system, an untapped opportunity for therapeutic intervention. Our proprietary Gene Traffic Control® platform gives us an integrated, mechanistic understanding of how the various components of the chromatin regulatory system interact, allowing us to identify, validate and potentially drug targets within the system. The Company, currently in the clinical stage, is advancing over 10 small molecule and protein degrader programs across a wide range of cancers.

Foghorn was founded in 2016 by Cigall Kadoch, Ph.D., Gerald Crabtree, M.D., and Doug Cole, M.D., of Flagship Pioneering. Learn more about Foghorn at  www.foghorntx.com .

About the Chromatin Regulatory System

The chromatin regulatory system regulates gene expression by directing the movement of molecules that turn genes on and off. Disease dependencies associated with the chromatin regulatory system are estimated to impact over 2.5 million cancer patients across the United States, Europe and Japan. This system is further implicated in neurological, autoimmune, and other serious diseases.

Job Summary

The successful candidate will be joining the computational chemistry team at Foghorn Therapeutics. S/He will be expected to drive and influence molecular design approaches by applying state of the art computational chemistry science. Of particular importance is the candidate's ability to build strong working interactions with medicinal chemists and structural biologists. The successful candidate will be a part of the chemistry team.

Key Responsibilities

  • Work in close partnership with medicinal chemists as a united compound design team to improve potency, selectivity, and ADME properties while minimizing toxicological risk

  • Help to further develop the computational chemistry infrastructure and software tools within Foghorn

  • Develop deep understanding of project SAR, and in concert apply cutting edge computational chemistry methods to influence team strategy and compound design, and ultimately positively impact project direction

  • Maintain and develop working knowledge of contemporary computational chemistry methods and their use in ligand design and data analysis as applied to drug design projects

    Qualifications

  • Ph.D. in a relevant scientific discipline with at least 4+ years of Computational Chemistry experience within a biopharma company

  • Sufficient experience and confidence to operate independently as the computational chemistry expert within the project team and represent computational chemistry in a variety of cross-functional contexts

  • Strong familiarity with a wide range of current computational chemistry and cheminformatics software tools/toolkits

  • Expert molecular designer with creativity & the ability to design ligands & libraries; utilizes tools to evaluate/prioritize ideas

  • Highly collaborative, team oriented professional with a passion for drug design

  • Experience with ligand and structure based computational chemistry activities

  • A working knowledge of synthetic chemistry to enable independent compound design of synthetically tractable targets

  • Preferred but not required – QSAR model building, method development, and informatics experience; familiarity with high throughput screening; design and modeling of hetero-bifunctional degraders

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