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Foghorn Therapeutics Scientist/ Senior Scientist/ Principal Scientist, Computational Chemistry in Cambridge, Massachusetts


Through its Gene Traffic Control? Product Platform, Foghorn® Therapeutics is discovering and developing an unprecedented class of medicines targeting diseases with genetically determined dependencies in the chromatin regulatory system. The Company, currently pre-clinical stage, is rapidly advancing over 10 programs across a wide range of cancers and is beginning to explore other diseases.

The chromatin regulatory system orchestrates the movement of molecules that turn genes on and off. Disease dependencies associated with chromatin dysregulation are estimated to impact approximately 2.5 million cancer patients in G7 countries and chromatin dysregulation is further implicated in neurological, autoimmune, and other serious diseases. Foghorn?s proprietary Gene Traffic Control Product Platform is based on the Company?s unique insights into the chromatin regulatory system and enables highly scalable drug discovery and development efforts.

Foghorn, a Flagship Pioneering® company, was founded in 2016 by Cigall Kadoch, Ph.D., Gerald Crabtree, M.D., and Doug Cole, M.D., of Flagship Pioneering. Learn more about Foghorn at


The successful candidate will be joining the computational chemistry team at Foghorn Therapeutics. He/ she will be expected to drive and influence molecular design approaches by applying state of the art computational chemistry science. Of particular importance is the candidate?s ability to build strong working interactions with medicinal chemists and structural biologists. The successful candidate will be part of the chemistry team.

Responsibilities include:

  • Work in close partnership with medicinal chemists as a united compound design team to improve potency, selectivity, and ADME properties while minimizing toxicological risk

  • Help to further develop the computational chemistry infrastructure and software tools within Foghorn.

  • Develop deep understanding of project SAR, and in concert apply cutting edge computational chemistry methods to influence team strategy and compound design, and ultimately positively impact project direction

  • Maintain and develop working knowledge of contemporary computational chemistry methods and their use in ligand design and data analysis as applied to drug design projects.


  • Ph.D. in a relevant scientific discipline with at least 4+ years of Computational Chemistry experience within a biopharma company

  • Expert molecular designer with creativity & the ability to design ligands & libraries; utilizes tools to evaluate/prioritize ideas

  • Experience with ligand and structure based computational chemistry activities

  • A working knowledge of synthetic chemistry to enable independent compound design of synthetically tractable targets

  • Preferred but not required ? QSAR model building, method development, and informatics experience; familiarity with high throughput screening; design and modeling of hetero-bifunctional degraders

  • Significant experience and confidence to operate independently as the computational chemistry resource within the project team and represent computational chemistry in a variety of cross-functional contexts

  • Strong familiarity with a wide range of current computational chemistry software tools

  • Highly collaborative, team oriented professional with a passion for drug design