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Bristol Myers Squibb Principal Scientist, Early Target Biology in Cambridge, Massachusetts

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Principal Scientist, Early Target Biology

The new Bristol-Myers Squibb research site in Cambridge's Kendall Square will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities. The Mechanisms of Cancer Resistance (MoCR) Thematic Research Center (TRC) at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current oncology therapies and implement our discovery platforms across all of our therapeutic areas of focus.

The Principal Scientist will join the Oncology Early Target Biology group at Bristol-Myers Squibb (BMS) in Cambridge, MA to identify, validate, and advance early stage cancer therapeutic targets by leveraging functional genomics based approaches that interrogate tumor intrinsic and tumor immunobiology mechanisms.


The qualified candidate is a highly motivated, interactive, and creative individual who possesses substantial experience in the genetics and signaling mechanisms fundamental to tumor biology and is interested in applying this knowledge to seek and validate targets for next generation therapies. The candidate will help shape future target discovery strategies and would be responsible for developing and executing on functional genomics based approaches to identify, validate, and advance targets into the drug discovery portfolio. The candidate will also have the opportunity to lead multi-disciplinary drug discovery teams as targets progress and will be expected to work seamlessly with colleagues across the BMS Thematic Research Centers, as well as with collaborators in the in vivo pharmacology, translational research, drug discovery, and medicinal chemistry groups. The highly matrixed nature of this role provides a unique opportunity to broaden scientific expertise into both cancer intrinsic and extrinsic drivers of resistance.


  • PhD with at least 5 years of relevant experience and demonstrated expertise in cancer biology and genetics, oncogenic signaling or DNA damage response pathways, and the identification and validation of targets using state-of-the-art functional genomics techniques, is required

  • Demonstrated expertise in executing on target identification strategies including the design, execution, validation of targets from forward and reverse genetic and/or phenotypic screens, and use of genome engineering techniques and genetic perturbation (eg shRNA, CRISPR, degron tagging of endogenous loci) is required.

  • Demonstrated expertise in uncovering mechanistic biology that best inform target modality for drug discovery efforts is preferred.

  • The candidate is expected to have experience supervising, mentoring and developing direct reports

  • Excellent interpersonal and communication skills with the ability to interact effectively with internal and external colleagues is required.

  • Competitive candidates are expected to have a record of independent and innovative research as evidenced by publications in top tier peer-reviewed journals.

Job Responsibilities include

  • Conceive, communicate and execute on multi-disciplinary research strategies that encompass target validation; deciphering mechanistic insight for target modality, biomarker identification to enable early patient stratification hypotheses, and early development of novel therapeutics

  • Working closely with project teams, key stakeholders, and colleagues in Drug Discovery, In Vivo Pharmacology, and Translational Research and play a leadership role in developing preclinical data sets to inform target modality, patient stratification and rational combination strategies for novel therapeutics.

  • Develop and utilize cell models that more closely mimic human cancer to enable the discovery of novel biology, answer mechanistic questions, and discover and validate potential therapeutic targets.

  • Work as a member of a diverse and motivated team of researchers from across Discovery Oncology and key internal and external collaborators

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol Myers Squibb

Req Number: R1525106-en-us

Updated: 2021-03-04 01:42:05.052 UTC

Location: Cambridge,Massachusetts

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.