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Oncorus Principal Associate Scientist, Analytical Development in Cambridge, Massachusetts

Principal Associate Scientist ? Analytical Development

Oncorus is a clinical-stage biotechnology company focused on developing next-generation viral immunotherapies to transform outcomes for cancer patients. Based in the vibrant Kendall Square, MA biotech ecosystem and backed by group of leading institutional life sciences investors, we are advancing a portfolio of intratumorally and intravenously administered viral immunotherapy candidates based on our oncolytic herpes simplex virus-1 and synthetic virus platforms for multiple indications with significant unmet needs. Our team is driving innovation and engineering multiple candidates with both platforms to potentially enable us to deliver on the full potential of this exciting therapeutic class. We believe every cancer patient deserves a better outcome. And we?re working with urgency to make that happen. Please visit to learn more.


We are seeking a highly motivated and skilled candidate for the role of Principal Associate Scientist on our Analytical Development & Quality Control team. This candidate will be involved in method development and optimization as well as routine analysis to support the characterization of our oncolytic Herpes Simplex Virus (oHSV) and lipid nanoparticle (LNPs) programs. The ideal candidate will be expected to execute experiments independently, collect data, and report on their findings in a well-planned and coordinated manner. This person should be excited by technical challenges and the ability to grow as a scientist as part of a novel viral gene therapy development team. This position will be based in the Company?s new state-of-the-art, Development and GMP viral immunotherapy clinical manufacturing facility being built in Andover, Mass, anticipated to open in the third quarter of 2021.

Summary of Key Responsibilities:

  • Perform full analytical testing to support oHSV and LNP product characterization, including plaque forming assays, cell-based expression assays, ELISAs, qPCR, gel electrophoresis, HPLC/UPLC and DLS.

  • Support the development of new assays to improve detection and characterization of viral vectors, LNPs, and process impurities.

  • Lead projects to drive analytical assay optimization, development, qualification and technology transfer.

  • Work independently on multiple high priority projects and deliver quality data within program timelines.

  • Support clinical drug product supply through review, analysis and troubleshooting of Quality Control release and stability.

  • Collaborate cross functionally with Process Development and Research teams to support development studies as well as with Quality Assurance to ensure compliance of Quality Control operations.

  • Document work in an electronic laboratory notebook.

  • Independently analyze, compile and present experimental data in oral presentations.

  • Assist with organization of lab, regular maintenance of mammalian cell lines, critical laboratory reagents and troubleshooting of advanced equipment.


  • B.S. degree in Biology, Biochemical Engineering, Biochemistry, Molecular Biology, or closely related field.

  • B.S. degree with minimum of 6 years? industry experience or M.S. degree with 4+ years? industry experience.

  • Hands-on experience with one or more of the following techniques: cell-based assays (i.e. transfection/infection etc.), ELISAs, qPCR, HPLC or DLS required.

  • Prior experience with analytical development and product characterization.

  • Hands-on experience with viral and LNPs products is highly desired.

  • Previous experience involving QC data review, trending and investigations as well as an understanding of current GxPs guidelines is a plus.

  • A motivated, self-starter who takes the initiative to identify key next steps in driving projects to completion (i.e. proactively tests new method or technologies, utilizes literature to solve scientific problems, etc.).

  • Strong communication and organization skills, good working knowledge of MS office, data plotting and graphing software (i.e. SoftMax, JMP, etc.).

  • Strong technical writing skills to ensure timely technical protocols, reports and SOPs are generated to summarize completed work.

  • Demonstrates attention to detail, meticulous record keeping and personal organization.

Oncorus is an EEO employer committed to an exciting, diverse, and enriching work environment.