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Merck Senior Scientist in Boston, Massachusetts

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

The Discovery Pharmaceutical Science group based in Boston, Massachusetts is seeking a Senior Scientist.

Discovery Pharmaceutical Science is a multi-disciplinary research group that provides drug delivery, solid-state, solution chemistry, and formulation tools in Drug Discovery and Early Drug Product Development. You will be responsible for the characterization of potential pre-clinical drug candidates' physicochemical properties and the identification of suitable oral and parenteral preclinical formulations for pharmacology and toxicology studies across a variety of administration routes and modalities (small molecules, peptides, proteins, oligonucleotides, and biotherapeutics).

In this exciting role, you will provide support to our discovery therapeutic areas based at our multi-disciplinary drug discovery site based in Longwood. You will also dedicate time to building support for our Exploratory Science Center based in Cambridge, Massachusetts which is focused on the earliest stages of discovery research. Finally, you will also closely interact with other key functions required for the progression of clinical candidate selection including Safety Assessment, Process Research, Analytical Chemistry, Drug Metabolism and Pharmacokinetics.

Responsibilities include executing lab research in the following areas:

  • Molecule profiling for both small and large molecules

  • Early formulation screening for stability and performance

  • Development of prototype and concept formulations/drug delivery which would benefit the molecule given its therapeutic area.

  • Research areas include solubilization, inhalation, targeted delivery, intracellular delivery, and modification of drug release.

  • Execution of physical and chemical methods (X-Ray Diffraction, Thermogravimetric Analysis, Differential Scanning Calorimetry, Dynamic Vapor Sorption, High-Performance Liquid Chromatography, High Performance Size-Exclusion Chromatography, Differential Scanning Fluorimetry, Dynamic Light Scattering, Microscopy).

  • Limited travel to scientific conferences and broader Pharmaceutical Sciences department meetings (< 5%)

Position Qualifications:

Required Experience and Skills:

Successful candidates will have a minimum of a Bachelor’s with a minimum of 7 years relevant experience OR a Master’s with a minimum of 5 years relevant experience OR a PhD with less than 1 year of relevant experience.

Excellent verbal and written communication skills are required. Strong leadership/interpersonal skills and a motivation to work in a team environment with cross-functional interactions are essential.

Preferred Experience and Skills :

Candidates with experience in pre-clinical / clinical formulation development and physico-chemical characterization are preferred. Candidates with specific experience of drug delivery for immunology and microbiome applications including the delivery of novel modalities are also preferred.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.






In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

US and Puerto Rico Residents Only:

If you need an accommodation for the application process please email us at

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We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:




VISA Sponsorship:


Travel Requirements:


Flexible Work Arrangements:


1st - Day

Valid Driving License:

Hazardous Material(s):

Handling of Merck research compounds

Number of Openings:


Requisition ID: R72139