Merck Senior Scientist, Cheminformatics in Boston, Massachusetts
New hires based in the US & Puerto Rico will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law.
Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.
Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.
The department of Computational & Structural Chemistry is seeking a creative and self-motivated cheminformatics data scientist to improve our ability to understand and predict complex biological endpoints, including toxicity and safety observations. The successful candidate will work closely with project teams, medicinal chemists, and preclinical experts to analyze complex in vitro and in vivo biological data. They will impact drug discovery at the hit-to-lead and lead optimization stages by developing robust data pipelines and predictive models, and combining individual experimental results and predictions to de-risk safety liabilities.
Responsibilities include, but are not limited to the following:
Develop and apply machine learning pipelines and models to complex biological endpoints (e.g., safety)
Develop generalizable data workflows that combine experimental data and predictions to inform decisions on projects
Characterize the toxicology profile of lead molecules and mitigate potential adverse effects
Collaborate and educate colleagues to increase data fluency and drive adoption of computational models for complex endpoint prediction
Education Minimum Requirement:
Ph.D. (or close to completion) in a relevant field such as Chemistry, Mathematics, Physics, Computer Science, or Biology.
Required Experience and Skills:
Competency in programming, scripting, and databases (e.g. Python, R, SQL)
Basic understanding of methods for cheminformatics, statistical analysis, visualization tools, and machine learning techniques
Strong communication skills, both written and oral
Ability to work well in multidisciplinary teams
Experience with data modeling and data pipelines in a life science setting
Experience with workflow applications and data analytics software (Pipeline Pilot, Knime, Spotfire)
External scientific visibility through multiple publications and/or presentations
A basic understanding drug discovery and medicinal chemistry
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.
Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth .
Invent. Impact. Inspire.
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.
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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
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Requisition ID: R159473
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