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Rhythm Pharmaceuticals Principal Scientist, Genetics in Boston, Massachusetts

Company Overview

Rhythm is a biopharmaceutical company aimed at developing and commercializing therapies for the treatment of rare genetic diseases of obesity. Working at Rhythm means that you are part of a team that’s passionate about transforming the lives of people living with rare genetic diseases of obesity. We recognize the courage it takes for patients and their caregivers to begin their journey of advocacy to find the answers they need. Their courage inspires us to challenge convention, ask bold questions and seek answers for them. Every day, we strive for excellence through our willingness to adapt, learn, and our tenacity to overcome barriers, together.

Job Summary

Rhythm Pharmaceuticals is seeking a talented Principal Scientist, Genetics to join the Translational Research and Development (TRAD) team. Rhythm is a precision therapy biotechnology company developing treatments for rare genetic diseases of obesity (RGDO).

The successful candidate will work closely with TRAD colleagues & external partners to carry out analyses of large-scale clinical and genomic databases. This person will collaborate with Rhythm’s clinical & biostatistics functions to further our understanding of the relationship between rare genetic variation, clinical & biochemical phenotypes and response to therapy.

This role will play a critical role in defining Rhythm’s precision medicine strategy for identifying and treating individuals with RGDO.

Responsibilities and Duties

  • Analyze large external and internal genomics databases, including data generated from Next Generation Sequencing and SNP arrays.

  • Design and analyze studies for biomarker discovery and validation.

  • Integrate data across multiple data sources, including publicly available data, internally generated sequencing data sets, and clinical electronic health records

  • Generate standardized clinical data sets for pooled analyses and/or meta- analyses of genotypes and phenotypes

  • Conduct association analyses of single genetic variants, gene-based scores, and multi-gene composite genotypes

  • Develop and implement pipelines to efficiently analyze associations across multiple phenotypes in multiple data sets using established and novel methods

  • Build and maintain collaborative relationships with external partners

  • Contribute to the planning, design and execution of translational R&D objectives

  • Generate analyses to support Rhythm’s scientific and clinical publication strategy

    Qualifications and Skills

  • PhD/ScD and 3+ years of work experience

  • Degree in Genetic Epidemiology, Statistical/Population Genetics, Computational Biology, Bioinformatics, Clinical Informatics, or related field preferred

  • Up-to-date knowledge of current statistical methods, tools, and algorithms for analyzing population genetics data

  • Prior clinical informatics and/or genetic epidemiology experience required

  • Proven ability to design and execute on genetic epidemiology studies within large clinical databases; previous experience with rare disease preferred

  • Expertise in R, Python, and other programming and scripting languages

  • Ability to integrate information to interpret results from genetic and clinical studies

  • Creative thinker, problem solver, innovator, good communicator and team player

  • Industry/Biotech experience preferred

  • Strong team player

    This role is based in our Corporate office in Boson, Massachusetts. Candidates applying must be willing and able to be in the Boston office once it is safe to do so, per State and Federal COVID-19 guidelines.

    This role will involve future travel, TBD post availability of COVID-19 vaccine

More about Rhythm

Rhythm is a biopharmaceutical company aimed at developing and commercializing therapies for the treatment of rare genetic disorders of obesity. The company is targeting the melanocortin-4 receptor (MC4R) pathway that is impaired due to genetic variants. This is a key biological pathway that regulates weight and hunger. A central element of Rhythm’s mission is to improve the understanding of these disorders and develop management strategies for patients who have no treatment options available to them. Rhythm was founded in 2008 and is based in Boston, MA. The company’s clinical development program is currently focused on several rare genetic disorders of obesity, all driven by genetic variants in the MC4R pathway. For healthcare professionals, please visit for more information. For those who may be affected or would like to learn more, visit for more information.

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