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Alexion Pharmaceuticals Director, Chief of Staff, Strategy, Program & Portfolio Management in Boston, Massachusetts

Position Summary:

As a member of the Strategy, Program and Portfolio Management (hereafter called SPPM) Leadership Team, the Chief of Staff will operate as a senior level operations liaison and thought-partner on a variety of strategic initiatives, on-going internal and external deliverables, and special projects, working with the Head of SPPM, the SPPM leadership team, and other Alexion functions especially R&D, Commercial, Corporate Communications and finance. This role supports the head of SPPM and the leadership team by ensuring the critical activities, communications and initiatives of the function are fully aligned and progressing. The Chief of Staff will also play a key role in the AstraZeneca integration efforts. Other projects and deliverables may vary.

Principal Responsibilities:

The Chief of Staff, SPPM plays an instrumental role in providing strategic and operational support to the Head of SPPM and the leadership team to enhance goal clarity, engagement, organizational efficiency, communications and strategic alignment with stakeholders and partners throughout Alexion.

This leader will also support and/or represent the Head of SPPM in internal and external meetings, including planning with critical constituents and content providers to ensure clarity of scope and objectives; leading the compilation and/or creation of appropriate briefing materials, including the development of presentations; and coordinating events (e.g., internal or external speaking engagements, Town Halls), as needed.

Operational Excellence

  • Enable operational excellence by understanding all facets of Strategy, Program and Portfolio Management and working with leadership to investigate and diagnose opportunities for improvement and partnering to identify solutions which increase collaboration or efficiency

  • Support a culture of excellence by instilling a culture of accountability by setting clear expectations, measuring results, and rewarding the right behaviors. Ensure adherence to all compliance guidelines, policies, and procedures

    Chief of Staff

  • Act as the conductor for the harmonious flow of work. Plan and direct all administrative and operational activities for the organization including:

  • Weekly staff meetings, including agenda planning and invitation of guest presenters

  • Monthly all hands meetings, including agenda planning and invitation of guests and coordination with the SPPM LT

  • Drive alignment and coordination of efforts across the SPPM LT as well as work with other CoS or SPPM colleagues on initiatives

  • Identify, raise/share, and implement best practices

  • Ensure consistency in over-arching processes and systems, where needed. For example, coordinate functional line goals and periodic review of progress against objectives

  • Develop partnerships with key colleagues in other functional areas to ensure ongoing alignment of goals and strategies and increased efficiency

  • Partner with Human Resources Leadership to ensure effective organizational planning, communications regarding organizational changes, talent development, and more

  • Manage and track commitments made by the Head of SPPM by executing follow-up activities as appropriate and ensure Leadership Team and staff implementation; summarize content of incoming materials, as requested

  • Coordinate with Chiefs of Staff across R&D to complete projects, share information and align messaging

  • Budgeting and planning oversight in collaboration with the Head of SPPM

    Strategic Projects

  • Provide oversight and guidance to projects of high importance and work closely with SPPM LT to help communicate and provide updates

  • Create strategic documents and presentations (e.g., Board of Directors presentations, Research Town Halls, contributions to R&D Town Halls, metrics, functional line planning, capacity assessments, etc.) in collaboration with other business partners; play a key role in the development of the Strategy, Program and Portfolio Management goals by working with key business partners to drive an effective and efficient and transparent process

  • Lead multidisciplinary cross-functional teams on behalf of the Head of SPPM, as requested

  • Ensure that requests for action and information from SPPM, other functions and external constituents are furnished in a timely, coordinated manner; effectively handling correspondence and communications involving both routine and complex matters


  • • The candidate must possess 8-10 years of industry experience, within middle to upper management positions

  • The candidate must have experience in Pharma/BioTech being familiar with the drug development process in various areas.

  • The candidate must have excellent communication skills, demonstrated ability to synthesize complex information from varying resources to guide executive updates, decision making and strategic planning

  • The ideal candidate must also have strong leadership skills, in particular the ability to influence others, including senior leaders, without direct authority

  • The successful candidate will be a well-organized, creative, independent, self-motivated individual with exceptional presentation, written, and oral communication skills

  • The candidate must have demonstrated business acumen; strong project management skills, the ability to handle multiple tasks simultaneously; the ability to respond to tight timelines; as well as, the capability to interact with all levels of the organization in a professional and discrete manner

  • Strategic thinker; strong analytical and business skills

  • Proven ability to develop a range of creative solutions to business challenges.

  • High energy level and sense of urgency with the ability to thrive under pressure, extremely responsive

  • Strong interpersonal skills, organizational maturity, and ability to develop a network of trusted relationships with peers and other stakeholders

  • Highly adaptable and comfortable with navigating through ambiguity


  • Bachelor’s degree is required; advanced degree strongly preferred

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Some opportunities happen only once in a lifetime - like a job where you have the extraordinary opportunity to change lives. At Alexion, such opportunities arise through our unwavering mission to serve patients and families affected by rare diseases. These patients are our guiding star, and we act with integrity, urgency, and discipline because we know their lives are at stake.

Alexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases and devastating conditions through the discovery, development and commercialization of life-changing medicines. As a leader in rare diseases for more than 25 years, Alexion has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), as well as the first and only approved complement inhibitor to treat anti-acetylcholine receptor (AchR) antibody-positive generalized myasthenia gravis (gMG) and neuromyelitis optica spectrum disorder (NMOSD). Alexion also has two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare metabolic disorders, hypophosphatasia (HPP) and lysosomal acid lipase deficiency (LAL-D) as well as the first and only approved Factor Xa inhibitor reversal agent. In addition, the company is developing several mid-to-late-stage therapies, including a copper-binding agent for Wilson disease, an anti-neonatal Fc receptor (FcRn) antibody for rare Immunoglobulin G (IgG)-mediated diseases and an oral Factor D inhibitor as well as several early-stage therapies, including one for light chain (AL) amyloidosis, a second oral Factor D inhibitor and a third complement inhibitor. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on the core therapeutic areas of hematology, nephrology, neurology, metabolic disorders and cardiology. Headquartered in Boston, Massachusetts, Alexion has offices around the globe and serves patients in more than 50 countries. Further information about Alexion can be found at:

As a leading employer in our industry, Alexion is proud to offer a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more.