Merck Boston Pharmacokinetics, Dynamics, Metabolism and Bioanalytics – Principal Scientist in Boston, Massachusetts
At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our company's Research Labs in Boston, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.
The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Principal Scientist to contribute to our company's drug discovery and early clinical development efforts. This position will be based at our research labs in Boston, MA. The ideal candidate will lead PDMB efforts as a portfolio leader, project-team representative and people manager across multiple modalities (primarily biologics focused, with opportunities to expand to small molecules, peptides, and targeted therapies), regularly interacting with multi-disciplinary discovery teams and subject matter experts from other functions within our Research & Development Division. Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well. The successful candidate will be expected to contribute to the strategic vision of the Boston PDMB group, represent PDMB on cross-functional teams and effectively mentor and develop direct reports.
In this exciting position, your primary roles will include:
Project-team representative and subject matter expert on PDMB activities in support our Research & Development Division's Immunology and Oncology therapeutic areas, with activities including (but not limited to) characterization of in vitro and in vivo ADME and pharmacokinetic properties across multiple modalities, implementing fit-for-purpose bioanalytical strategies and building translational pharmacology relationships (PK/PD) around the impact of drug disposition on disease biology and pharmacological response.
Potential to manage multiple direct reports (both project-team representatives and lab-based staff) in support of global PDMB activities.
Close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) aimed at building highly efficient strategies to identify and optimize drug candidates.
Education Minimum Requirement
- Ph.D (with 6+ years relevant experience) or Master’s (minimum of 10 years relevant experience) or Bachelor's (minimum of 14+ years of relevant experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field; Relevant experience to include a record of increasing responsibility and independence in a similar industrial/academic setting.
Required Experience and Skills
Demonstrated project-team leadership contributing to development, execution, and fostering of translational pharmacokinetic/pharmacodynamic/efficacy relationships across multiple modalities.
Technical ability to interpret and provide context around data describing the pharmacokinetic and pharmacodynamic properties of protein therapeutics (monoclonal antibodies and engineered proteins)
Formal people management experience with demonstrated experience in supervising and mentoring research scientists.
Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast-paced environment.
Preferred Experience and Skills
Proven track record supporting immunology and inflammation-based programs with experience spanning from early discovery through IND-enabling efforts.
Ability to design and interpret novel, hypothesis-driven ADME and bioanalytical strategies (LC/MS and/or ligand-binding assays) to support the optimization of monoclonal antibodies, engineered proteins, biologics, small molecules, and targeted therapies.
Familiarity with engineering strategies to improve pharmacokinetic and pharmacodynamic properties of protein therapeutics.
Experience working within a research-driven pharmaceutical company.
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Requisition ID: R271750
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