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Merck Boston Pharmacokinetics, Dynamics, Metabolism and Bioanalytics – Principal Scientist in Boston, Massachusetts

Job Description

At our company, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our company's Research Labs in Boston, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Principal Scientist to contribute to our company's drug discovery and early clinical development efforts. This position will be based at our research labs in Boston, MA. The ideal candidate will lead PDMB efforts as a portfolio leader, project-team representative and people manager across multiple modalities (primarily biologics focused, with opportunities to expand to small molecules, peptides, and targeted therapies), regularly interacting with multi-disciplinary discovery teams and subject matter experts from other functions within our Research & Development Division. Therapeutic area support with focus on our immunology and oncology portfolios, with the potential to contribute to cardiovascular/metabolic, neuroscience and infectious disease efforts as well. The successful candidate will be expected to contribute to the strategic vision of the Boston PDMB group, represent PDMB on cross-functional teams and effectively mentor and develop direct reports.

In this exciting position, your primary roles will include:

  • Project-team representative and subject matter expert on PDMB activities in support our Research & Development Division's Immunology and Oncology therapeutic areas, with activities including (but not limited to) characterization of in vitro and in vivo ADME and pharmacokinetic properties across multiple modalities, implementing fit-for-purpose bioanalytical strategies and building translational pharmacology relationships (PK/PD) around the impact of drug disposition on disease biology and pharmacological response.

  • Potential to manage multiple direct reports (both project-team representatives and lab-based staff) in support of global PDMB activities.

  • Close collaboration with Discovery and Early Development project teams in Boston (MA), South San Francisco (CA) and West Point (PA) aimed at building highly efficient strategies to identify and optimize drug candidates.

Education Minimum Requirement

  • Ph.D (with 6+ years relevant experience) or Master’s (minimum of 10 years relevant experience) or Bachelor's (minimum of 14+ years of relevant experience) degree in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering or related field; Relevant experience to include a record of increasing responsibility and independence in a similar industrial/academic setting.

Required Experience and Skills

  • Demonstrated project-team leadership contributing to development, execution, and fostering of translational pharmacokinetic/pharmacodynamic/efficacy relationships across multiple modalities.

  • Technical ability to interpret and provide context around data describing the pharmacokinetic and pharmacodynamic properties of protein therapeutics (monoclonal antibodies and engineered proteins)

  • Formal people management experience with demonstrated experience in supervising and mentoring research scientists.

  • Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast-paced environment.

Preferred Experience and Skills

  • Proven track record supporting immunology and inflammation-based programs with experience spanning from early discovery through IND-enabling efforts.

  • Ability to design and interpret novel, hypothesis-driven ADME and bioanalytical strategies (LC/MS and/or ligand-binding assays) to support the optimization of monoclonal antibodies, engineered proteins, biologics, small molecules, and targeted therapies.

  • Familiarity with engineering strategies to improve pharmacokinetic and pharmacodynamic properties of protein therapeutics.

  • Experience working within a research-driven pharmaceutical company.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.


Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

Current Employees apply HERE ($1533/rel-task/3001$14.htmld)

Current Contingent Workers apply HERE ($4020.htmld)

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here ( if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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EEOC GINA Supplement​

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts (

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Flexible Work Arrangements:

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Requisition ID: R271750