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Homology Medicines, Inc. Research Associate I, Analytical Development in Bedford, Massachusetts

Homology Medicines, Inc. is seeking a Research Associate I to join our Analytical Development team. This key team member will collaboratively develop and refine analytical methods to characterize AAV vector products. The motivated and engaging Research Associate I will bring their critical-thinking skills to focus on the analysis of research/development-grade vector samples using multiple AAV-specific analytical methods. This team player will participate primarily in the operation and development of the Analytical Ultracentrifuge, as well as participate in other molecular and bioanalytical assays, embracing a team-based culture and able to accommodate rapidly changing priorities while delivering high-quality results. This Research Associate I, Analytical Development role offers the opportunity to actively participate in the development and application of our technology platform to improve the lives of patients.

  • Plan and execute AAV-specific characterization assays including HPLC and CE, with a focus on Analytical Ultracentrifugation.

  • Generate, manage, and evaluate critical data in a highly organized manner, delivering high quality results verbally, in notes, and in reports and presentations.

  • Assist with technology transfer to contract manufacturing organizations by generating data and reports, as well as providing on-site technical support as necessary.

  • Assist with the qualification of methods internally.

  • Identify complex technical issues and implement solutions under supervision.

  • Contribute to the experimental design and optimization of new assays in collaboration with supervisor.

  • BS in Biological Sciences, Chemistry, or Pharmaceutical Sciences with 0-2 years of relevant industrial experience in analytical method development with an emphasis in biophysical analysis required.

  • Adept at conducting routine testing and able to conduct troubleshooting of multiple methods.

  • Excellent verbal and written communication, presentation, and interpersonal skills are essential.

  • Independently motivated, organized, and detail oriented, with sound problem-solving ability able to deliver high-quality results both independently and collaboratively is required.

  • Strong individual contributor who thrives in a collaborative team environment, where results are achieved through the incorporation of multiple points of view; able to embrace a team-based culture.

  • Able to effectively manage and prioritize multiple parallel laboratory activities is essential; flexible to accommodate rapidly changing priorities and deadlines.

  • Able to work collaboratively within the Analytical Development team as well as across the organization, with exceptional technical skills, organizational skills, interpersonal skills, and attention to detail.

  • Experience with method transfer to external testing organizations to support characterization and release of clinical stage products is preferred.

  • Experience working in Quality Control or understanding of GLP and GMP practices a plus.

  • Familiarity of Electronic Lab Notebook (ELN) and Laboratory Information Management Systems (LIMS) a plus.

Job ID: 2022-1197