Pfizer Scientist in Andover, Massachusetts
Scientist- Formulation and Analytical, is a position within the Drug Product Design and Development group, part of the Pharmaceutical Research & Development (PhRD) department in Pfizer's Biotherapeutics Pharmaceutical Sciences organization. This laboratory leadership role will be responsible for supporting formulation development and investigating physico-chemical characterization methods of Pfizer's biotherapeutics portfolio molecule formulations in a dynamic and highly interdisciplinary environment to support pre-clinical, clinical and commercial development. In addition, the candidate should be able to contribute towards formulation selection and characterization source documentation to support regulatory submissions. This position requires exceptional time management and communications skills with a strong attention to detail. A breadth of knowledge of analytical tools and techniques applied to materials science, colloidal structure and stability, nanotechnologies for formulation design, nucleic acid drug delivery and general pharmaceutical R&D is required.
The incumbent candidate will be responsible for conducting experiments in support of evaluating and characterizing formulations/processes, components and supporting delivery technologies for RNA-based medicines as well as other diverse therapeutic modalities (e.g. mammalian and microbial fermentation derived candidate molecules, vaccines, plasmids, peptides, and targeted delivery strategies). This individual function cooperatively with other members of the team to achieve the project goals. The incumbent displays strong drive in learning new techniques and scientific commitment, and impactful scientific and technical contributions within the PhRD team and the respective project teams. Specific responsibilities include:
Develop/transfer methods and execute to analyze experiments for existing and novel modalities.
Support development of novel characterization techniques to characterize formulations to support process development and formulation design.
Be the point of contact for analytical needs to support formulation and process development. Compile experimental and analytical results, perform data interpretation, summarize, and report on data with conclusions
Interface with Analytical R&D (ARD) and represent PhRD on ARD project teams to ensure project continuity across the different line functions.
Provide technical representation and subject matter expertise (SME) in cross functional analytical investigations for clinical and commercial production processes
Contribute towards defining the appropriate parenteral dosage form, formulation, process design, scale up approaches, identify critical parameters, and define the design space
Interface extensively in a matrixed environment with process and analytical development teams for process investigation support, assess new analytical technologies, support on-going process characterization and post-approval changes.
Communicate research and development findings internally and externally.
MS. in Pharmaceutical Sciences, Analytical Chemistry, Biophysics, Biomedical Eng, Chemical Eng, Biochemistry, Biotechnology, or equivalent scientific field with 5 years related experience (or BS with 8+ years of experience).
Solid foundation in Formulation, analytical, chemistry, material science, and/or nano-particle technologies.
Experience in formulation development, pharmaceutics, drug product manufacturing or scale-up of biotherapeutics modalities.
Effective communication skills and the ability to write technical reports
Experience with analytical technologies used in characterizing mRNA-based modalities and/or nanoparticle modalities (RNA quantitation assay, CGE, light scattering, ddPCR, particle characterization technologies, etc.)
Experience in nucleic acid drug development (DNA, RNA, oligonucleotides)
Experience with regulatory filings and submissions.
Exceptional organizational, communication, and critical thinking skills, and the ability to thrive in an interdependent and idea-rich environment
Strong work ethic and attention to detail
Relocation support available
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