Pfizer Head of Precision Medicine in Cambridge, Massachusetts

Reporting to the Senior Vice President, Early Clinical Development, this senior executive is responsible for implementing a Precision Medicine (PM) approach to Pfizer's discovery and development efforts in a portfolio that spans a wide range of clinical areas (Immunology and Inflammation, Cardiovascular/Metabolic, Neurosciences, Rare Diseases, and Oncology).

The scope of PM responsibilities includes enabling robust decision making centered around POM, ESOE, and PoC which will ultimately lead to increased probability of technical success in later development, patient selection/stratification/ phenotyping, and the potential for diagnostics. In addition, there is potential to partner with the pre-clinical organization to build robust human translation plans that underpin the design and delivery of clinical candidates.

S/He will be a champion for PM within the company, and will maintain organizational focus on the effort through visible, active involvement in both research and clinical programs. Serving as a "go-to" advisor to the Head of Early Clinical Development and Chief Scientific Officers (CSOs), s/he ensures a PM approach is applied to all project transitions (e.g., from Proof of Mechanism to Proof of Concept), and coordinates cross-functional PM efforts. The Head of Precision Medicine will supervise both laboratory and non-laboratory based colleagues who are collectively responsible for PM strategy and execution at both the team and study levels. S/He is ultimately responsible for developing, obtaining consensus for and implementing patient segmentation plans and strategies.

A strategic thinker, the Head of Precision Medicine provides oversight and implements patient segmentation hypotheses, strategies and prioritization by providing clarity around potential pre-clinical and clinical investments to support PM goals, and the costs and tradeoffs for these investments. S/He will review clinical results and oversee data mining across Pfizer's relevant portfolio to inform future PM decision making. S/He will also contribute to the formulation of biomarker and clinical development plans. May contribute to the review of the pre-clinical package after soliciting appropriate input, review and endorsement from key stakeholders for go / no-go development decision criteria.

This seasoned executive is adept at communicating information to senior staff and maintains a professional demeanor to develop effective collaborations with internal and external constituencies including regulatory, other industry, KOLs, consultants, and professional and academic organizations. S/He is an active participant in regulatory and other professional circles. In conjunction with development team members, prepares strategy presentations, presents and discusses data at relevant team, governance, external consultant, KOL, and regulatory meetings.

Strategic thinking is balanced with an ability to work within a matrixed team of international colleagues, including other clinicians, statisticians, clinical pharmacologists and others, to get things done. The Head of PM is responsible for tracking PM project progress against key goals, providing administrative and technical oversight and leadership of functions within his/her group in preparation of critical documents, and monitoring and reporting on implementation of global initiatives in the group.

Ultimately, it will be the PM Head's responsibility to ensure development and implementation of RU (Research Unit) specific precision medicine efforts, strategies and standards and in collaboration with other functions, and that all activities within the group are conducted in compliance with relevant regulatory requirements. S/He will develop charters, resource utilization and project plans to achieve project specific goals, be accountable for analyses, outputs, and integrated scientific reports for biomarker projects supporting clinical trials and support for relevant publication activities, and implement strategies to ensure appropriate consistent processes in strong collaboration with associated RU partners. S/He will need to stay at the forefront of biomarker technologies, internally and externally, and drive the investment agenda across technology platform and portfolio needs.


The successful candidate is an MD, or MD/PhD, with a depth and breadth of knowledge and experience in clinical development and basic research in the academic, clinical practice or industry setting demonstrated by a history of publications in peer-reviewed journals, meeting abstracts, etc. Experience in generating and interpreting high-dimensional data sets, including effective communication with computational biologists, is essential. Strong skills in professional/scientific communication and writing are also required. A thorough understanding of relevant areas such as biostatistics, regulatory, pre-clinical pharmacology, pharmaceutical sciences, and diagnostics is necessary. S/He may be experienced in (particularly early) clinical trial design and execution, including early Proof of Mechanism studies in an industrial setting utilizing biomarker-based approaches, and will be comfortable analyzing the associated complex datasets.

An important element of the role is extensive experience in leading and managing laboratory (regulated genomic, ligand binding, flow cytometry, mass spectrometry, transcriptomic, and protein biomarker capabilities) and non-laboratory teams in an industrial setting including proven skills in taking the lead in difficult decision making situations, and identifying, hiring and on-boarding new talent. The role is also expected to collaborate closely with the imaging and engineering group as part of the organization's biomarker endeavors. The successful candidate will lead an existing team of 30-40 FTEs. Cross functionally, s/he will be expected to maintain and improve upon a culture of collaboration between clinical and research activities within the company, and to foster an environment that encourages strong partnerships and mutual trust between teams, sub-teams, and leaders. S/He will lead by example with a sense of pace and urgency, and will exercise initiative in meeting goals and drive innovation in projects.

EEO Statement

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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Additional Offer Details:

  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

A career at Pfizer offers opportunity, ownership and impact.

All over the world, Pfizer colleagues work together to positively impact health for everyone, everywhere. Our colleagues have the opportunity to grow and develop a career that offers both individual and company success; be part of an ownership culture that values diversity and where all colleagues are energized and engaged; and the ability to impact the health and lives of millions of people. Pfizer, a global leader in the bio-pharmaceutical industry, is continuously seeking top talent who are inspired by our purpose to innovate to bring therapies to patients that significantly improve their lives.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.